A principle aim of this study was to establish the correlation between real time and accelerated in-vitro degradation of biodegradable polymer film composed of poly-L-lactic acid (PLLA) polymer. The effort of establishment of this correlation was to determine feasibility of carrying out accelerated in-vitro degradation study as a substitute of real time degradation study which was proven to be more time consuming. A degradation behavior of biodegradable PLLA polymer was evaluated on each stage of total degradation period up to six month and 15 days for real time and accelerated respectively during in-vitro degradation under simulated environment condition. Various series of samples were employed for study and degradation progress was investigated based on the change in mass loss, molecular weight, crystallinity and visual observation at each interval during degradation period by comparing with initial results. Reasonable evidence of results for degradation progress suggests the implementation of accelerated in-vitro degradation study as a fast quality control tool of PLLA properties evaluation.
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